The results showed that the metabolic alterations described in cellular and animal models of ADPKD (Figs. 1–3) and recapitulated by the mathematical model (Fig. 6a, b) and by the murine microarrays (Fig. 6c) are all perturbed in ADPKD1 kidneys including GLY, PPP, oxidative TCA cycle (TCA/OXPHOS), FAS, and FAO. Here, FAS is linked to autosomal dominant polycystic kidney disease.