In line with this, the starvation from both glucose and glutamine drastically enhances cell death in cells lacking Pkd1. Thus, inhibitors of Asns along with the glycolytic inhibitor 2-deoxy-d-glucose11,12 might offer a good therapeutic strategy in ADPKD and further studies should be devoted to test this possibility. The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.