More than 1,800 different mutations have been identified in FBN1, most of which are associated with MFS, as seen in the Universal Mutation Database (UMD)-FBN1 mutations database (Collod-Beroud et al., 1997; Collod et al., 1996) using a generic software called UMD (Collod-Beroud et al., 2003). Here, FBN1 is linked to Marfan syndrome.