Finally, we show both in vitro and with tumor xenograft models that ET190L1-AbTCR-T cells maintain comparable anti-tumor potency to ET190L1-CAR and CD137-based CTL019 T cells, yet T-cell activation through ET190L1-AbTCR results in lower concentrations of inflammatory cytokines. This evidence concerns the gene TNFRSF9 and neoplasm.