Given our previous findings demonstrating that DVL-1 plays a critical role in regulating a TIAM1-Rac1 signaling axis in MDA-MB-231 cells [5], and endogenous DVL-3 co-precipitates with SIRT1 in breast cancer cells [22], we were interested in exploring these two family members in particular. This evidence concerns the gene TIAM1 and breast carcinoma.