As shown in three independent experiments in a panel of breast cancer cell lines (Figure 3C), we found that both DVL-1 and DVL-3 bind the I.1 promoter in MCF7, MDA-MB-231 and BT-549 while only DVL-3 binds to I.1 in MDA-MB-468. The gene discussed is DVL1; the disease is breast carcinoma.