In addition, the chance of having an impaired or severely impaired hypoglycemia unawareness decreased with higher age (OR 0.98, 95% CI 0.97–0.99), after adjusting for gender, HbA1c, duration/type of diabetes and insulin therapy, frequency of blood glucose monitoring, knowledge and fear of hypoglycemia, psychosocial well-being, severe and non-severe hypoglycemia events. The gene discussed is INS; the disease is diabetes mellitus.