A higher proportion of T1DM patients that experienced severe hypoglycaemia (compared to T2DM patients) have consulted their physician/nurse (60.2% vs. 48.3%), increased calorie intake (74.4% vs. 63.3%), avoid physical activity (37.3% vs. 27.3%), reduced insulin doses (91.6% vs. 44.1%) and increased the number of times checking blood glucose (76.5% vs. 50.8%). The gene discussed is INS; the disease is type 1 diabetes mellitus.