SERPING1 and hereditary angioedema: According to the CHAEN member’s survey, the main concerns expressed by physicians treating patients with HAE in Canada were: sample shipping and handling, having to wait a long time to get results, lack of recognized laboratories for genetic testing, diagnosis of nlC1-INH-HAE, testing of F12 and other susceptibility genes (cost and availability) and ability to develop a reliable functional C1-INH assay, the basic testing for HAE diagnostic.