Non-Tregs among CD4+ T cells did not differ among patients with MGUS (19.88% ± 2.24%, P = 0.136), with untreated myeloma patients (18.92% ± 2.81%, P = 0.22) and healthy adults (18.79% ± 2.13%) (Fig. 2c). This evidence concerns the gene CD4 and plasma cell myeloma.