The frequency of rTregs among CD4+ T cells did not show any significance in MGUS patients (6.16% ± 1.34%, P = 0.72) and MM patients (5.69% ± 0.98%, P = 0.074) against healthy controls (6.35% ± 0.94%) (Fig. 1b). This evidence concerns the gene CD4 and Miyoshi myopathy.