Third, we noticed that sporadic cancer with high mutation frequency for the NF1 gene (e.g. melanoma, glioblastoma, lung, skin, and ovarian cancer), rarely, if ever, develop in NF1 patients, although they have already lost one copy of NF1 (Supplementary Table 1; Supplementary Table 2). The gene discussed is NF1; the disease is glioblastoma.