Taken together, our research showed that KLF8 induced angiogenesis in HCC by binding to the CACCC region of the VEGFA promoter to induce VEGFA promoter activity and through FAK to activate the PI3K/AKT signaling pathway to increase P-PDK1(Ser241) levels; then, increased P-AKT(Thr308) or P-AKT(Ser473) and HIF-1α levels induced VEGFA protein expression. This evidence concerns the gene PDK1 and hepatocellular carcinoma.