KLF8 and neoplasm: In nude mice livers, the tumor weights of the SMMC7721-pcDNA3.1-KLF8 group were significantly greater than those of the SMMC7721-pcDNA3.1 group (3.6 ± 0.6 g vs 1.0 ± 0.3 g, P < 0.01, n = 3) (Fig. 8a,b).