KLF8 is a member of the Krüppel-like C2H2 zinc-finger transcription factor family of proteins9, KLF8 induces tumor cell epithelial-to-mesenchymal transition (EMT), maintains the invasive potential of cancer, and plays a crucial role in the metastatic progression of human carcinoma10–12. The gene discussed is KLF8; the disease is neoplasm.