As expected, overexpression of LMP2A in NPC cells (CNE2 and HNE1) led to increases in the levels of phosphorylated AKT, mTOR, 4E-BP1, S6K and ribosomal protein S6, accompanied by upregulation of HIF-1α (Fig. 6b). This evidence concerns the gene HIF1A and nasopharyngeal carcinoma.