FOXO3a is a downstream effector of EGFR and the PI3K pathway, which via p38 mitogen‐activated protein kinase (MAPK) inhibition can induce cell cycle arrest and is a key mediator of the cytotoxic effect of cisplatin in colorectal cancer (Fernández de Mattos et al., 2008; Germani et al., 2014). This evidence concerns the gene EGFR and colorectal cancer.