PSEN2 and Alzheimer disease: Custom capture and deep sequencing of the genomic regions of these four genes revealed 107 candidate post-zygotic mutations but only 3 could be confirmed by amplicon-based deep sequencing: two novel MAPT missense mutations of unknown significance in sporadic AD patients (variant allele frequencies of 1.0% and 1.1%) and one known PSEN2 likely benign missense mutation (variant allele frequency of 1.6–5.7%) in a control.