FUS and amyotrophic lateral sclerosis: For example, a frequency of 1% FUS mutation carriers was found among 500 cases with sporadic ALS (mean age at onset: 60 years), including one DNM in the blood of a patient with an onset at 36 years [167], but higher FUS mutation detection rates were reported when screening series of younger sporadic patients, as for example, 3/11 (27%) [188] and 6/14 (43%) [67] in patients with an age of onset of less than 25 and 35 years, respectively.