FUS and amyotrophic lateral sclerosis: The FUS gene is the most recurrently hit gene by DNMs in sporadic ALS with 9 different DNMs reported in 18 independent cases (Table 3 Supplementary Table 2) [4, 17, 31, 38, 39, 45, 66, 67, 78, 93, 167, 188], compared to only one in SOD1 [7], one in VCP [13], one in the novel gene ERRB4 [166] and two in the MAPT gene in the FTLD spectrum [25, 117], including one shared by two siblings indicating a mosaic DNM encompassing the germline in one parent [25].