Specifically, we found that many diseases such as systemic lupus erythematosus, hepatitis, leukemia, cancer, and other related biological molecules such as estrogen, prolactin, oxytocin, GnRH, aldosterone, renin, thyroid hormone, insulin, glucagon, gastric acid could also indirectly affect the development of asthma, providing strong evidence for our hypothesis that MXGSD could treat asthma through systemic neuro-immuno-inflammatory regulation from a genetic perspective. Here, GNRH1 is linked to systemic lupus erythematosus.