ERBB2 and neoplasm: To identify the molecular features that are associated with trastuzumab activity in the clinical setting, we analysed tumour biopsies from patients with locally advanced primary HER2+ BC at diagnosis who underwent brief exposure to trastuzumab monotherapy.10 From a cohort of 28 patients, RNA samples with sufficient quality and quantity for gene expression profiling were available for matched pretreatment and 21-day samples (Tru-cut samples) for 17 subjects.