Our studies on the UUO-induced renal fibrosis confirmed that (1) AGP induction was observed following 1,25(OH)2D3 treatment both in vivo and in vitro (2) AGP treatment attenuated renal fibrosis and inflammation in the UUO mice (3) AGP played an anti-inflammatory role in THP-1-derived macrophages with or without LPS stimulation. Here, ATP5MK is linked to renal fibrosis.