CD274 and neoplasm: Quantitatively, on our reduced dataset of manually annotated regions, the percentage of pixels in PD-L1 positive tumor cell region that are wrongly classified as being in a macrophage region is less than 7%, the percentage of pixels in macrophage region that are classified as being in a PD-L1 positive tumor cell region is less than 14%, specifically showing the ability of the proposed system to differentiate between different types of PD-L1 stained cell regions.