In the molecular signature database (MSigDB), these five genes are involved with oncogenic signaling, e.g., androgen response (IRF2BP2), hypoxia (GPI, HMOX1), mTORC1 (GPI), mitotic checkpoint (KIF3C), and poor prognosis mutant drivers of prostate cancer, e.g., TP53 (HMOX1) and PTEN/AKT (EDARADD). This evidence concerns the gene HMOX1 and Familial prostate cancer.