In the molecular signature database (MSigDB), these five genes are involved with oncogenic signaling, e.g., androgen response (IRF2BP2), hypoxia (GPI, HMOX1), mTORC1 (GPI), mitotic checkpoint (KIF3C), and poor prognosis mutant drivers of prostate cancer, e.g., TP53 (HMOX1) and PTEN/AKT (EDARADD). The gene discussed is IRF2BP2; the disease is Familial prostate cancer.