We find that five of these genes (IRF2BP2, EDARADD, GPI, HMOX1, KIF3C) were over-expressed in patient samples (Fig. 2k), and the overexpression was significantly associated with prostate cancer relapse (the onset of metastatic disease) as individual (Fig. 2j) and as a group (Fig. 2l). This evidence concerns the gene IRF2BP2 and Familial prostate cancer.