Fetal liver-derived HSCs derived from Bak−/−, Bak−/−Bax−/− or Bak−/−Vdac2−/− mice at E14.5 were retrovirally transduced with the c-MYC oncogene and transplanted into lethally-irradiated mice to induce AML (Fig. 6 and Supplementary Fig. 8a)31. Here, BAK1 is linked to acute myeloid leukemia.