MDM2 and lung adenocarcinoma: For instance, under genotoxic conditions, IKKβ acts as a regulator of p53 via the association with β-TrCP1 in MEF cells to destabilize its protein levels, independent of Mdm2, and the loss of IKKβ via chemical inhibition in lung adenocarcinoma cells reduced proliferation and invasion in these cells, and was accompanied by the stabilization of p5339,40.