In order to shed light on the clinical significance of Jag1 expression in CLL, we examined whether there was a correlation between the expression levels of Jag1-FL in CLL cells and some CLL prognostic factors, including IGVH mutational status, expression of ZAP70 and CD38, and 11q and 13q deletions. This evidence concerns the gene CD38 and B-cell chronic lymphocytic leukemia.