GAPDH and colorectal cancer: Furthermore, it was also demonstrated in colorectal cancer cells that VC selectively kills KRAS and BRAF mutant cells, increasing endogenous ROS which inhibits glyceraldehyde 3-phosphate dehydrogenase (GAPDH) by both posttranslational modifications and nicotinamide adenine dinucleotide (NAD)+ depletion, leading to an energetic crisis and cell death10.