IGF1 and neoplasm: To evaluate the effect of the newly engineered IGF-TRAPs on the growth of colon carcinoma liver metastases, mice were inoculated with (5 × 104) murine colon carcinoma MC-38 cells via the intrasplenic/portal route and subsequently injected intravenously from day 1 post tumor injection with the IGF-TRAPs at doses ranging from 0.5–10 mg/kg.