IGF1 and hyperinsulinemic hypoglycemia, familial, 4: To determine whether the retention of the IGF-TRAPs in the liver was due to preferential ligand binding in this organ, we compared IGF-TRAP 3.3 accumulation in livers of wild type mice and mice with a conditional, liver-specific, IGF-I deficiency (iLID) induced by a single tamoxifen injection3,20.