In line with this, diabetes-associated alterations in the peripheral nerve phenotype and concomitant development of sensorimotor dysfunction were accompanied by decreased expression of AMPK-PGC-1α-eNOS signaling and this was ameliorated by cinacalcet treatment through the upregulation of AMPK-eNOS phosphorylation in the sciatic nerve of diabetic mice. This evidence concerns the gene NOS3 and diabetes mellitus.