DLBD, diffuse lewy body disease; *, MSA-nigrostriatal type; ADNC, Alzheimer disease neuropathologic change; AGD, argyrophilic grain disease; TDP-MTL, TDP-43 proteinopathy in medial temporal lobe; ALS, amyotrophic lateral sclerosis; PART, primary age-related tauopathy. The gene discussed is TARDBP; the disease is Alzheimer disease.