40 and 41. This concept applies to synucleinopathies and other neurodegenerative diseases. We have found distinct conformations of tau will propagate indefinitely and produce predictable and transmissible pathology upon inoculation (34, 42, 43). Other groups have found evidence of conformation-dependent patterns of neuropathology in various β-amyloidoses (44, –, 47). The gene discussed is MAPT; the disease is neurodegenerative disease.