CD274 and non-small cell lung carcinoma: Nevertheless, despite the results of clinical trials with PD-1 [4, 5, 10, 11] and PD-L1 [7, 12, 13] inhibitors have been promising, the overall objective response rates in NSCLC patients who received such therapy were about 20%, and most patients had primary resistance [3–5, 7, 10–12].