WWTR1 and obstructive sleep apnea syndrome: This is in agreement with the lack of reports of similar associations in human OSA, and possibly reflects the fact that a major determinant of whether or not TAZ and YAP protein levels are sustained to ultimately lead to a cellular response depends on post-translational modifications, such as phosphorylation events, which direct the proteasome-dependent degradation of these transcriptional co-activators.