YAP1 and osteosarcoma: Taken together with the consistent reduction of viability across cell lines upon YAP knockdown (Fig. 6b), and the significance of such effects in the presence of Doxorubicin, our results suggest a key role for YAP in canine osteosarcoma survival and possibly in proliferation, and are in agreement with the associations of YAP with time to metastasis and overall survival suggested by the TMA analysis.