Our results showing that TRPM7-mediated CSCs-like phenotype in lung cancer is modulated by Hsp90α/uPA/MMP2 signaling is therapeutically-relevant and partially consistent with recently demonstrated role of TRPM7 in the regulation of pancreatic cancer cell invasion through the Hsp90α/uPA/MMP2 pathway [26]. Here, PLAU is linked to pancreatic neoplasm.