Since lung cancer is a heterogeneous disease with the presence of CSCs being demonstrated in lung cancer and implicated in the metastatic and treatment-resistant phenotype of malignant lung cells (23), we examined if TRPM7 exhibits any modulatory effect on the CSCs- like phenotype of lung cancer cells and their associated aggressiveness, by evaluating the effect of TRPM7 on the protein expression of stemness markers. The gene discussed is TRPM7; the disease is lung cancer.