In conclusion, as depicted in our schematic summary (Fig. 6), we have provided evidence that aberrant TRPM7 expression induces the cancer stem cell-like and metastatic phenotypes of aggressive human lung cancer cells through positive modulation of the Hsp90α/uPA/MMP2 signaling pathways and induction of pluripotency transcription factors. The gene discussed is TRPM7; the disease is lung cancer.