Moreover, TRPM7 has been shown to regulate CSCs in glioma by modulating Notch and STAT3 signaling pathways [17, 18], however, it’s probable role in the modulation of lung cancer stem cells, induction of metastatic and drug-resistant phenotypes, its facilitation of poor prognosis, and likely targetability by therapeutic agents are unexplored in lung cancer patients and serve as the subject of our present study. This evidence concerns the gene TRPM7 and lung cancer.