Similar to the findings in breast cancer stem cells [30], and consistent with its role in CSCs-derived primary tumor growth, we demonstrated that TRPM7-dependent targeting of highly expressed Hsp90α in lung CSCs inhibits tumorsphere formation, reduces the number of lung cancer SP cells and potentiates the anticancer effect of standard chemotherapeutics such as doxorubicin and cisplatin (Fig. 4a-d). Here, HSP90AA1 is linked to lung cancer.