This TRPM7-associated expression profile is disease-relevant because the migration of cancer cells requires activation of genes necessary for differentiation, impede proliferative activities, induce anti-apoptotic mechanisms, transform the cells from epithelial to mesenchymal phenotype, suppress receptors that facilitate cell-to-cell attachment, degrade cell-to-cell junctions, and enhance cell motility [24]. Here, TRPM7 is linked to cancer.