BAK1 and lung cancer: Furthermore, we showed that shRNA- mediated reduction of TRPM7 expression significantly suppressed the viability of lung cancer cells, attenuated the ability of the malignant cells to form colonies, and impeded their cell migration and invasion; all these were associated with concomitant downregulation of apoptotic marker Bak and mesenchymal markers Vimentin, and Snail, as well as upregulation of epithelial marker E-cadherin and tumor suppressor p21 (Fig. 3).