Our in silico analysis of TCGA-AML cases (162 patients treated with curative intent) also showed that abnormalities in IFN-γ-responsive genes, occurring in 30% of cases and including mRNA up-regulation and gene amplification, correlated with shorter event-free survival and OS, suggesting the hypothesis that IFN-γ-dominant TME profiles, while defining resistance to cytotoxic chemotherapy, may predict response to immune based therapy [84]. Here, IFNG is linked to acute myeloid leukemia.