The interrelationships among inflammatory, survival, and Wnt/β-catenin signaling cascades also uncovered a complete regulatory loop impacting in both neurogenesis and neuronal outcome upon injury, protecting mDAergic neurons from loss in the MPTP mice model of PD through inflammatory inhibition, via activation of PI3K/phosphorylated (p)-Akt and Wnt1/Fzd1/β-catenin cell signaling pathways [49,50,51,52,53,54,55,56,57,160,161], thus prompting further investigations along these lines. This evidence concerns the gene FZD1 and Parkinson disease.