VPS35 and Parkinson disease: Importantly enough, the earlier identification of Wntless, a sorting receptor for Wnt, and of the retromer, a protein complex required for the recycling of Wntless from endosomes to the trans-Golgi network [118,119], support a critical role for Wnt-dependent functions in “vesicle trafficking, recycling, and turnover, that may be central to the pathophysiology of PD” [118], with VPS35 mutations being potentially involved in dysregulation of Wnt secretion.