The identification of at least 12 genes involved in familial PD, including α-synuclein (SNCA), Parkin, Ubiquitin hydrolase, PTEN-induced putative kinase, DJ-1, leucine-rich-repeat kinase (LRRK2), vacuolar protein sorting 35 homolog gene (VPS35), and Glucocerebrosidase (GBA), linked to autosomal dominant late-onset PD, provided new clues to the pathogenesis of PD [9,66,67,68,69,70]. The gene discussed is VPS35; the disease is Parkinson disease.