Interestingly, ablation of MAP1LC3B or SQSTM1 or both decreased tumorsphere formation and enhanced the killing effects of paclitaxel (PTX, Figure 7C,D), implying that MAP1LC3B and SQSTM1 might modulate autophagy for tumor growth and drug resistance in BMSCC cells. This evidence concerns the gene SQSTM1 and neoplasm.