Specifically, we have demonstrated that the orexigenic peptide ghrelin was able to inhibit 5-HT level in the hypothalamus of growth hormone releasing hormone (GHRH) knock out mice [44].While mutations on kisspeptin signaling have been related to precocious puberty (CPP) and idiopathic hypogonadotropic hypogonadism [45]. Here, KISS1 is linked to central precocious puberty.