Dox has proved to be a popular drug for aptamer modified DNA origami-based delivery: It has been used in a long linear DNA nanostructure decorated with a Sgc8c or an AS1411 motif [108]; a fluorophore labelled dendritic DNA nanostructure with Sgc8c for specific delivery to cancer cells in vitro [109] and DNA tetrahedron with both AS1411 and MUC-1 aptamers delivering Dox [110]. This evidence concerns the gene MUC1 and cancer.