DICER1 and infection: Furthermore, it is interesting to note that, in contrast to all RNA viruses tested (HIV-1, West Nile virus, yellow fever virus, influenza A virus etc.)that were refractory to depletion of endogenous miRNAs, HSV-1 replication was modestly but significantly decreased in Dicer KO cells [123], indicating that viral or host miRNAs might have a role during the productive infection.