ANGPT1 and amyotrophic lateral sclerosis: Therefore, the present investigation aimed to assess the efficacy of C16 and Ang-1 in ameliorating inflammation within the local microenvironment in an ALS/PDC rodent model and to further test whether this treatment pairing could promote the therapeutic effect of L-serine, which has been reported to reduce the risk of neurodegeneration triggered by the environmental toxin L-BMAA [13].