To further explore whether miR-150-5p inhibited CRC development through VEGFA-mediated Akt/mTOR signaling pathway, we found that miR-150-5p overexpression significantly decreased the level of VEGFA, and then significantly suppressed the phosphorylation of VEGFR2 (p-VEGFR2), Akt (p-Akt) and mTOR (p-mTOR) in HCT116 and HCT8 cells. This evidence concerns the gene KDR and colorectal carcinoma.