With this, we concluded that the CRISPR-dCas9-VPR-mediated transcriptional gene activation of FUT4 and FUT9 in MC38 cells can be reliably linked to the tumor-associated fucosyltransferase function, with Lewisx emerging as the main fucosylated epitope that these enzymes synthesize in common in the context of colorectal cancer. This evidence concerns the gene FUT9 and colorectal cancer.