With this, we concluded that the CRISPR-dCas9-VPR-mediated transcriptional gene activation of FUT4 and FUT9 in MC38 cells can be reliably linked to the tumor-associated fucosyltransferase function, with Lewisx emerging as the main fucosylated epitope that these enzymes synthesize in common in the context of colorectal cancer. The gene discussed is FUT4; the disease is colorectal cancer.