In the present study, we exploited the CRISPR-dCas9-VPR system for transcriptional activation of certain α1-3 fucosyltransferase genes, Fut4 (Giordano et al. 2015) and Fut9 (Auslander et al. 2017), playing a major role in colorectal cancer pathogenesis. This evidence concerns the gene FUT9 and colorectal cancer.