CD209 and cancer: This is supported by the fact that DC-SIGN binding to Lewis antigens overexpressed by cancer cells, results in induction of T helper 2 (Th2) and regulatory T (Treg) cells, decreased activity of natural killer (NK) cells and increased production of anti-inflammatory cytokines, such as interleukin-10 (IL-10) (Rodríguez et al. 2018).