IMMT and Hydrocephalus: G555fs deletion mutant, predicted to truncate 248 amino acids of the C-terminal domain, which are important for cargo binding in Kinesin motor proteins [13]; and (ii) a conditional CMV-Cre;Kif6tm1c/tm1c mutant which recombines exon 4 leading to an early frame shift mutation predicted to generate a N-terminal truncated 122 amino acid KIF6 protein (Table 2), both of which display indistinguishable progressive, hydrocephalus with EC ciliogenesis defects.