EIF5 and uveal melanoma: Recently, we established that substituting the conserved basic residues, as well as the yeast equivalents of eIF1A NTT residues identified as recurring substitutions in certain human uveal melanomas, decreases initiation at UUGs in vivo and selectively destabilizes PICs reconstituted at UUG codons in vitro (Martin-Marcos et al., 2017), as described above for eIF5-NTD hyperaccurate Ssu- substitutions.