In transgenic mouse models of lung cancer, Dusp6 RNA was present at significantly higher levels in the lungs of mice bearing tumors driven by mutant EGFR or KRAS transgenes than in normal mouse lung epithelium (Figure 2D) (Felsher and Bishop, 1999; Fisher et al., 2001; Politi et al., 2006). Here, EGFR is linked to lung carcinoma.