(B) Relative P-ERK levels (ratio of phosphorylated to total levels normalized to actin) were determined by dosimetry and compared to the vehicle controls (0 BCI = 0.1% DMSO) to quantify the relative increase after BCI treatment from the gels in A. (C) Increase of P-ERK promotes sensitivity of lung cancer cell lines without KRAS or EGFR mutations to BCI. The gene discussed is MAPK1; the disease is lung carcinoma.