Among these genes, CAMTA1, CDC42 and RNF138 have been reported as oncogenes in multiple cancers,17, 18, 19 while CREBRF was a tumor suppressor in glioblastoma and a tumor promoter in gastric cancer.20, 21 Furthermore, CAMTA1 and CDC42 could interact with several lncRNAs to make significant effects on the tumorigenesis.22, 23. The gene discussed is RNF138; the disease is gastric cancer.