GJA1 and neoplasm: Multivariate Cox regression analysis demonstrated that Cx43 expression, either membranous or cytoplasmic, was independent of tumor size, grade, stage, and ER-status in predicting breast cancer-specific (membrane p = 0.003; cytoplasmic p = 0.004) and metastasis-free survival (membrane p = 0.003; cytoplasmic p = 0.005) (Table 3).