CD8A and neoplasm: Significantly higher density of CD8+ cells (median 402.56 vs. 121.32; Z = − 10.0411, p < 0.0001) and Foxp3+ T cells (median 113.53 vs. 28.49; Z = − 10.0969, p < 0.0001) were found in the surrounding tissues than those within the tumor nests.