Moreover, inflammatory effectors equally contributed to cachexia, and sulindac as anti-inflammatory drug was very effective in ameliorating the severity of cachexia and reduced UCP1 mRNA expression levels in cachectic mice.6 These experiments show that preventive treatments combined anti-inflammatory drugs and β3-AR blockade may be effective in ameliorating the severity of cancer cachexia. This evidence concerns the gene UCP1 and Cachexia.