PPARG and breast cancer: As shown in a previous study, the inhibition of PPARγ phosphorylation at S273 induces UCP1 overexpression in adipocytes.20 As shown by our results, total and phosphorylated PPARγ levels significantly decreased in adipocytes incubated with breast cancer cells and adipocytes overexpressing miR-155, while miR-155 knockdown in cultured breast cancer cells rescued the reduced levels (Figure 5D).