Several types of tumors show decreased expression of p27, including breast, colon, esophageal carcinomas, head and neck cancers, hematological tumors lung, prostate, melanomas and ovarian tumors.1,15 The decreased expression of p27 is due to increased proteasome-mediated protein degradation, correlates with poor prognosis of patients. The gene discussed is CDKN1B; the disease is carcinoma of esophagus.