These data indicate that loss of p27 is retained as a feature of early (CAH) and neoplastic endometrial lesions arising in the setting of obesity.18 Similar findings are observed in other types of human cancers.1,23 p27 is reduced in premalignant and non-invasive cancerous lesions, including ductal carcinoma in situ of the breast. This evidence concerns the gene CDKN1B and ductal breast carcinoma in situ.