For example, EGFR G719C is a well-known actionable mutation in patients with lung adenocarcinoma (17, 18), and patients with FGFR W290C mutation-positive tumor were reported to be sensitive to FGFR inhibitors (19), but these mutations were determined as VUSs by WfG ver.27 (false negative examples). The gene discussed is EGFR; the disease is neoplasm.