BRAF-SULT4A1 and its reciprocal fusion SULT4A1-BRAF were evaluated as pathogenic; BRAF fusions, such as KIAA1549-BRAF, have been reported in astrocytoma, (21) supporting the conclusion that this fusion is likely pathogenic. This evidence concerns the gene SULT4A1 and astrocytoma (excluding glioblastoma).