Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) antibody primarily blocks inhibitory signaling of T cell priming and activation while programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) antibody primarily recovers attenuated anti-tumor immune response in tumor bed [6]. Here, PDCD1 is linked to neoplasm.