APOE and Alzheimer disease: APOE £4 has been found in a greater frequency in both patients with “pure” (no co-pathology) LBD and those with LBD and AD co-pathology compared to the general population [18], and some post-mortem studies find an independent association of APOE £4 with SYN pathology [58,67], which further reinforces a link between this common risk variant and LBD.