The pathologic substrates linked to dementia in PD are diverse and include a range of histopathological findings, including the distribution of Lewy SYN pathology in the neocortex [56–58], subcortical cholinergic loss [14,59], Cerebrovascular Disease (CVD) [60], Argyrophilic Grain Disease (AGD) [61], TAR DNA-binding protein 43 (TDP-43) inclusions in limbic structures [62] and hippocampal sclerosis of aging (HpScl) [63]. The gene discussed is TARDBP; the disease is cerebrovascular disorder.