In this respect, several recent studies in patients with SCA3, the most frequent SCA subtype, have yielded promising results.SIRT1 encodes sirtuin-1, an NAD+-dependent deacetylase involved in several cellular functions, including chromatin modulation, the cell cycle, apoptosis, and autophagy regulation in response to DNA damage. The gene discussed is SIRT1; the disease is autosomal dominant cerebellar ataxia.