GRM1 and spinocerebellar ataxia type 1: It also affects the development of new therapeutic approaches: for example, elucidation of the role of mGluR1 in the excitability of Purkinje cells led to experiments modulating mGluR1 activity in SCA1 mice with drugs such as baclofen or the negative allosteric modulator JNJ16259685, both of which improved motor function75,76.