TNC and respiratory system disorder: In patients with high serum TNC and periostin levels, the percentages of GINA treatment steps 4 + 5 (P = 0.042), percentages of patients with aspirin-exacerbated respiratory disease (AERD) (P = 0.004), daily dose of ICS (P = 0.045), and peripheral blood eosinophil (P = 0.005) and neutrophil counts (P = 0.032) were significantly higher, whereas FVC (P = 0.01), %FVC (P = 0.019), FEV1 (P = 0.014), PEF (P = 0.045), MMF (P = 0.045), and %MMF (P = 0.042) were significantly lower as compared with patients in the other subpopulations (Table 3).