Elicited protective humoral immunity was likely responsible for the clearance of Plasmodium in TACI -/- mice because the delayed clearance of P. yoelii coincided with the late emergence of anti-malaria antibodies, and B cells transferred from P. yoelii immune TACI -/- mice afforded protection in naïve wild-type mice, and TACI -/- mice rechallenged with P. yoelii resisted infection. Here, TNFRSF13B is linked to malaria.